MarScreen
® IgA

MarScreen® IgG
MarScreen® IgM


 

Mixture of MarScreen IgA (red),
IgG (blue) and IgM (green) 
beads, 400X.


MarScreen IgG Beads and Antiserum mixed with 
sperm positive for antibodies. Note clumps of beads 
and sperm and clumps of beads alone, 400X




.
Description

Bead Method for the Detection of  Sperm-Reactive IgA, IgG, and IgM Antibodies

Features

Background

There is considerable evidence that antibodies directed against sperm surface antigens exert a
fertility-reducing effect.  When antisperm antibodies are present, they bind to the surface of the
sperm.  Such sperm-bound antibodies may impair sperm movement, penetration of the cumulus
and/or zona pellucida, the acrosome reaction, interaction of sperm and egg as well as identify the
sperm for destruction by the immune system.  It has also been suggested that sperm antibodies
may exert an embryotoxic effect.  Finally, there is evidence that antibody concentration is correlated
directly with the severity of sperm functional impairment and inversely with potential fertilizability.

For these reasons, many reproductive specialists screen sperm and/or serum for anti-sperm antibodies
before choosing an
appropriate Assisted Reproductive Technology.

Package Insert MarScreen IgA

Package Insert MarScreen IgG

Package Insert MarScreen IgM

MSDS MarScreen IgA, IgG, IgM

SDS

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